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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 4161) Last page : ( 4165)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00764.3

Low-Intensive Electropulse Therapy for Correction of Clinical and Functional Manifestations of Neuropathy in Multiple Myeloma

Drobyshev Victor A.1, Zakhariya Oleg I.2, Abramovich Stanislav G.3,*, Kadyrov Marsel A.4, Markov Alexander A.5

1Department of Hospital Medicine and Medical Rehabilitation, Novosibirsk State Medical University, 630091, Krasny Ave., 52. Novosibirsk, Russian Federation

2Department of Therapy, Hematology and Transfusiology, Novosibirsk State Medical University, 630091, Krasny Ave., 52., Novosibirsk, Russian Federation

3Department of Physiotherapy and Balneology, Irkutsk State Medical Academy of Postgraduate Education Branch of the Russian Medical Academy of Continuing Professional Education, 664049, 100 Yubileyniy Microdistrict, Irkutsk, Russian Federation

4Department of Geology of Oil and Gas Fields, Tyumen Industrial University, 625000, 56 Volodarsky Str., Tyumen, Russian Federation

5Department of Traumatology and Orthopedics with the course of children's traumatology INPR, Tyumen State Medical University, 625023, 54 Odesskaya Str., Tyumen, Russian Federation

*Corresponding Author E-mail: prof. Abramovich@yandex.ru

Online published on 20 December, 2018.


Polychemotherapeutic drugs can affect neuros system in patients with myeloma, which can worsen their quality of life and promote disease progression. The authors studied the dynamics of pain syndrome, microcirculation status and parameters of quality of life in patients with multiple myeloma complicated by peripheral polyneuropathy under polychemotherapy. In the course of the present study 106 patients were examined and divided into the three groups: in group I the patients were indicated standard polychemotherapy supplemented with the course of dynamic electroneurostimulation, in group II the patients were treated with placebo procedures along with the basic treatment, and in group III the patients received standard treatment. It was established that by the end of the therapy pain syndrome intensity decreased in patients from group I by 1.8 times, initially elevated pain threshold decreased by 24.4% and basal microcirculatory parameters improved by 1.4 times, whereas in the comparison groups significant changes were not observed. The treatment influenced on the quality of life: in group I the score of physical functioning (SF-36 questionnaire) increased by 1.5 times in comparison with the baseline, the score of general health perception and vitality increased by 1.7 and 1.5 times, respectively, which significantly differed from analogue parameters score in the comparison groups. It was established that introduction of dynamic electroneurostimulation into the treatment plan of patients with multiple myeloma reduced pains intensity, decreased pain threshold, stimulated microhemocirculation and contributed to improvement of quality of life that allowed the patients to continue their specific polychemotherapy.



Dynamic electroneurostimulation, peripheral polyneuropathy, pain syndrome, impulse amplitude, basal microcirculation.


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