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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 4135) Last page : ( 4142)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00760.6

In Vitro Free Radical Scavenging and Reducing Potentials as well as Inhibitory Potential on α-Amylase and α-Glucosidase Activities of Fruit of Morinda citrifolia (Rubiaceae).

Rao US Mahadeva*

Professor, School of Basic Medical Sciences, Faculty of Medicine, Universiti Sultan Zainal Abidin (UniSZA), 20400, Kuala Terengganu, Malaysia

*Corresponding Author E-mail: raousm@gmail.com

Online published on 20 December, 2018.

Abstract

Background

Reactive oxygen and nitrogen species produced via cellular metabolism and from exposure to environmental pro-oxidants appear to contribute to the pathogenesis of chronic disease via free radical damage to lipids, nucleic acids, and proteins. Literature review: Morinda citrifolia (MC) fruit is rich in phytochemicals necessary for treatment of diabetes.

Objective

The purpose of this study was to investigate the effect of MC fruit extracts’ free radical scavenging, and reducing potentials as well as inhibitory effect on α-amylase and αglucosidase.

Methods

The of percentage yield, phytochemical screening (both qualitative and quantitative), in vitro antioxidant and antidiabetic assays, and kinetic studies were performed with different solvent extracts of MC fruit pulp.

Results

MC inhibits α-glucosidase and α-amylase enzymes in the in vitro studies. The antioxidant and reducing potentials of the fruit extract gives strong biochemical rationale of their therapeutic potential.

Conclusion

Therefore the fruit extract of MC may play an important role in the development of nutraceuticals and also in the management of oxidative stress induced diabetes.

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Keywords

Phytochemical, α-Glucosidase, α-Amylase, Antioxidant, Nutraceutical.

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