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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 4104) Last page : ( 4107)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00754.0

Evaluation of the Antioxidant Activity of some Hydrazone Schiff's bases bearing Benzotriazole Moiety

Rahmani Salah Eddine1,*, Lahrech Mokhtar2

1Laboratory of Organic Chemistry and Natural Substances, University of Djelfa, 17000, Algeria

2Department of Biology, Faculty of Life and Natural Sciences, University of Djelfa, 17000, Algeria

*Corresponding Author E-mail: *rahmanidz@yahoo.fr

Online published on 20 December, 2018.

Abstract

In our work, a series of substituted hydrazone Schiff's bases of N-benzylideneacetohydrazide 2-(1H-benzo[d] [1, 2, 3] triazol-1-yl)-(B3-B12) were synthesized from the benzotriazole hydrazide and with the use of various aromatic aldehydes. The structure of the synthesized compounds was confirmed by IR, 1HNMR and Mass spectra. All the compounds were screened for in vitro antioxidant activity by DPPH scavenging and FRAP assay. The Results show that all the compounds have significant antioxidant activity. Compounds substituted with electron donating groups like methoxy and hydroxyl showed higher antioxidant activity.

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Keywords

Benzotriazole, Schiff base, DPPH, FRAP.

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