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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 4047) Last page : ( 4050)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00745.X

Synthesis, Characterization and Biological Evaluation of some Novel 1, 3 Oxazepine derivatives from Vanillin Schiff's Bases

Kadem Khudhayer J.*, Munahi Murad G.

Department of Chemistry, College of Science, University of Babylon, Iraq

*Corresponding Author E-mail: khudheyerbabel@yahoo.com

Online published on 20 December, 2018.

Abstract

A series of Schiff's bases and their novel derivatives (Oxazepines) have been synthesized, 4-hydroxy-3methoxy benzaldehyde (vanillin) was condensed with different amines to produce the Schiff's bases in the presence of glacial acetic acid as a catalyst or KOH, novel five 1, 3-oxazepine derivatives have been synthesized through reaction of Schiff's bases with succinic anhydride and maleic anhydride using acidic catalyst. The identification was performed using, FT-IR and1H-NMRspectroscopies. The synthesized1, 3-oxazepine derivatives were biologically screened against gram positive (Staphylococcus aureus) and gram negative bacteria (Escherichia coli). The Results was showed excellent to moderate anti-bacterial activity.

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Keywords

1, 3-oxazepine, Vanillin, Schiff's bases, anti-bacterial activity, disk diffusion method, cycloaddition.

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