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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 3881) Last page : ( 3886)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00711.4

Effects of Oxidative Stress on Alzheimer's Disease, Haematological Perspective

Al-Hatamleh Mohammad Ahmed Issa1, Al-Shajrawi Omar Mahmoud1, Khan Saif Ullah2, Nadeem Muhammad Ilyas1, Simbak Nordin Bin1, Latif Ahmad Zubaidi A.1, Baig Atif Amin1,*, Ariff Tengku Mohammad3,**

1Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia

2Factuly of Applied Social Sciences, Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia

3Institute for Community (Health) Development and Quality of Life (I-CODE), Universiti Sultan Zainal Abidin, Kuala Terengganu, Malaysia

*Corresponding Author E-mail: atifamin@unisza.edu.my

**tg_mariff@unisza.edu.my

Online published on 20 December, 2018.

Abstract

Alzheimer disease (AD) is considered among the most important neurodegenerative disorder in elderly individuals. AD patients have higher oxidative stress as compared to normal people with a higher susceptibility to health problems. Oxidative stress Results into several disorders including AD. Oxidative stress in AD patients may lead to abnormal red blood cells (RBCs) indices and elevated white blood cells (WBCs) count. Oxidative stress in AD patients can lead to massive destruction of red blood cells (RBCs). The brain and the gastrointestinal system are intimately connected, as one system. The brain has a direct impact on the GI tract. A stressful brain can send signals to the gut, just as a troubled intestine can send signals to the brain. Therefore, oxidative stress in AD patients can be reason for hindering the breakdown and assimilation of food for energy and nourishment. This malabsorption can then lead to a reciprocal negative effect on oxidative stress and also can be another cause of anaemia due to malabsorption of minerals and vitamins that are important to erythropoiesis. Therefore this review article is designed to unearth the effect of oxidative stress in AD patients and incite leading researchers to generate database that will help in understand the relationship between oxidative stress and haematological parameters especially in AD patients.

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Keywords

Alzheimer, Stress, Oxidative stress, Free radicals, Hematological parameters.

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