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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 9
First page : ( 3745) Last page : ( 3751)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00686.8

Sugar Palm Fruit (Arenga pinnata) Diminish Pain and Inflammatory Symptoms of Osteoarthritis in male Wistar Rat (Rattus norvegicus)

UmiKalsum1,*, Khotimah Husnul1, Riawan Wibi2, Trisnaini Hasnia Azizah3, Zubaidah Elok3

1Departement of Pharmacology, Medical School, Universitas Brawijaya, Indonesia

2Departement of Biochemistry and Molecular Biology, Medical School, Universitas Brawijaya, Indonesia

3Agricultural Technology Faculty, Universitas Brawijaya, Indonesia

*Corresponding Author E-mail: dr.umikaslum@gmail.com

Online published on 20 December, 2018.

Abstract

Sugar palm fruit is the seed of Aren fruit (Arenga pinnata) that contain galactomannan polysaccharides. Galactomannan is the polysaccharide that has analgesic activity. The purpose of this research was to determine the effect of analgesic and anti-inflammation of sugar palm fruit juice to the inflammation induced by 0.6% acetic acid and Complete Freund's Adjuvant (CFA) to male Wistar rats (Rattus norvegicus) respectively. Sugar palm fruit juice made by blending the sugar palm fruit and water which ratio 1: 2. The male rats were divided into 6 groups: control, induced with acetic acid 0.6% (analgesic) or CFA (inflammation), induced with acetic acid 0.6% (analgesic) or CFA (inflammation) and sodium diclofenac 10 mg/200 g BW of rats, and last three groups were induced by acetic acid or CFA and administered by sugar palm fruit extract dose 1, 2 and 3 mg/200 g BW. We used Fourier Transform Infrared (FITR) analysis to identify molecular structure of galactomannan in sugar palm fruit juice. The Results showed that sugar palm fruit juice reduced pain and edema in rats. The highest efficacy of analgesic and anti-inflammatory response was at 3 ml/200 g BW sugar palm fruit juice which potension of analgesic was 69.7% and anti-inflammatory response to decrease edema volume was 1, 608 ml. FITR peaks showed that galactomannan had main chain β-(1–4)-D_mano-pyranose and bind to D-galacto pyranose in α-1-6 chain. It could be concluded that sugar palm fruit juice potential to developed as analgesic and anti-inflammatory agent.

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Keywords

Anti-Inflammation, Anti analgesic, Galactomannan, Sugar palm fruit, Osteoarthritis.

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