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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3581) Last page : ( 3584)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00659.5

Neuroprotective Properties of Statins

Lekshmi R. S. Sree1, Shanmugasundaram P.2,*

1School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies [VISTAS], Chennai, India

2Director, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies [VISTAS], Vels University, Chennai, India

*Corresponding Author E-mail: samsimahe@gmail.com

Online published on 31 October, 2018.

Abstract

The risk of ischemic stroke between patients with increased risk of vascular disease is decreased by treatment with statins. Neuroprotective properties of statins in acute cerebral ischemia is pointed out in current experimental abstracts. There is an established fact in between bioavailability of nitric oxide and the activity of statins and ischemic stroke. Statins have been contemplated in the therapy of a number of the central nervous system disorders, including cerebral ischemia, Alzheimer's disease, Parkinson's disease, tumors, and trauma on account of their capability to up-regulate nitric oxide synthase. It has been asserted that they restrain inflammatory response and secondary injury after acute ischemia.

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Keywords

Statins, neuroprotection, Alzheimer's disease, multiple sclerosis, Parkinsons Disease.

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