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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 8
First page : ( 3503) Last page : ( 3508)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00648.0

Prevalence of Anti-Viral Drug Resistance Chronic Hepatitis B patients (CHB) in Iraq

Jawad Mustafa1, Hashim Kadhim1, Mahmood Abbas2

1Department of Biology, College of Science AL – Mustansiriyah University

2Central Public Health Laboratories-Ministry of Health

Corresponding Author E-mail: shekhar_bio@yahoo.co.in

Online published on 31 October, 2018.

Abstract

This study aimed to evaluate prevalence of Chronic Hepatitis B virus which antiviral drugs resistance. The study included 230 patients received from Hepatology and Gastroenterology Teaching Hospital and Central Public Health Laboratories/HIV/AIDS and Hepatitis Referral Laboratory (Baghdad), from April 2016 to February 2017. Selection of these samples depended on HBsAg positive, HBV DNA by PCR (positive) Follow up after 6 months end of treatment (INF-α, lamivudine). The total number CHB patients have HBs Ag positive, the prevalence of HBe Ag accounts for 18 (7.8%) HBe Ag positive while 212 (92.2%) were HBeAg negative. The drug resistant patient was 83 from 230 patients by 36%; 80 from 212 patient by 37% belong to HBeAg negative and 3 from 18 patient by 16.6% belong to HBeAg positive. Anti-HBc was 207 (90%) from all CHB. Anti-HBe Ag appears 118 (51.3%) from all CHB and (12%) in drug resistant patient group. Most of patients included within age groups from (20–29) years 60 (26%) patient and 45 (19.5%) patient in age group (30–39). HBe Ag positive and HBe Ag negative appear (27.9%) and (26%) Respectively. in age group (20–29) while in CHB patient drug resistance showed high percentage in age group (20–29) by 27(32.5%).Male to female ratio was (1.33:1) Where the number of males 130 (57%) while the number of females 100 (43%), HBe Ag positive group and HBe Ag negative group appear (1.25:1) and (1.33:1) respectively. while patients chronic hepatitis B drug resistant male to female ratio was (1.51:1) the number of males 50 (60.2%) while the number of females 33 (39.8%), HBe Ag positive group and HBe Ag negative group appear (2:1) and (1.5:1) respectively. The patients chronic hepatitis B who were drug resistant were divided into 60 patients HBe Ag negative and all 18 patients HBe Ag positive each one divided to high viral load and low viral load. Before and after of treatment, No significant differences were recorded for each group when compared to before and after treatment.

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