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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 3237) Last page : ( 3240)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00595.4

D Amino acid Oxidase-Role in Physiological process: A Review

Nithya S1, Dr. Shanmugarajan T. S.2,*

1Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-117

2Department of Pharmaceutics, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Pallavaram, Chennai-117

*Corresponding Author E-mail: smrajan@velsuniv.ac.in

Online published on 31 October, 2018.

Abstract

D-amino acid oxidase (DAAO) metabolizes exogenous D-Serine that acquires all through growing older, and might modulate the extent of availability of D-serine levels within the brain, appearing as a detoxifying agent. D Serine is the significant D Aminoacid in brain responsible for cognitive function. D-serine, a D-amino acid that is directed by DAAO, is an intense, endogenous co-agonist of the N-methyl-D-aspartic acid (NMDA) receptor. Since NMDA receptor dysfunction is believed to be associated with the positive (psychotic), negative effects in schizophrenia, there has been much enthusiasm for creating powerful and particular DAAO inhibitors for the treatment of these diseases. DAAO regulation in maintenance of D-aminoacid levels has been identified with a few physiological processes ranging from hormone secretion to synaptic transmission, Production of Neurotransmitters like Dopamine, Epinephrine and Norepinephrine and cognitive function. Various genetic examinations have distinguished a transformation on chromosome 13 in schizophrenia patients that encodes quality items (G30 and G72) which are identified with levels of DAAO in their brains. A few research reports have been portrayed the synthesis of novel, specific, small molecule inhibitors of DAAO. Many of these compounds, when administered, increased the D-serine levels in the blood and brain. Also, numerous examinations reveals the significance of DAAO expression and enzyme action has been said to be enhanced in submit mortem brain tissue samples from patients with schizophrenia compared with healthy controls. The present review gives the significance of DAAO and their involvement in different physiological process. Involvement of this protein in new drug development. This protein might be a good focus for different physiological studies for insight think in not so distant future. This article features the examination made on DAAOI

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Keywords

DAAO, Physiological process, regulation, Secretion, Amino acids.

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