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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 2922) Last page : ( 2925)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00539.5

Formulation and Evaluation of Risperidone Loaded Mouth-Dissolving Film

Sahu Hemlata, Alexander Amit, Gupta Swapnil, Yadav Pooja, Thapa Hemlata, Banjare Tripti, Agrawal Palak, Bhandarkar Akansha, Bhatt Aditi, Diwedi Shradha Devi, Sahu Pankaj, Sahu Siddharth Kumar, Sahu Kailash, Dewangan Deeksha, Deepika, Sharma Mukesh, Tripathi D. K., Ajazuddin*

Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024

*Corresponding Author E-mail: write2ajaz@gmail.com; ajazuddin@rungta.ac.in

Online published on 31 October, 2018.

Abstract

Mouth dissolving oral films are useful in patients such as paediatric, geriatric, bedridden or developmentally disabled who face difficulty in swallowing conventional tablets or capsules and liquid orals or syrups leading to ineffective therapy. Mouthdissolving films have been played an important role in the current pharmaceutical research. They have convenience and ease of use over other dosage forms such as orally disintegrating tablets and immediate release tablets. Mouth dissolving films are oral solid dosage form that disintegrate and dissolve within a minute when placed in mouth without taking water or chewing. Risperidone is effective for treating the positive and negative symptoms of schizophrenia compared to first generation antipsychotics. But oral administration of Risperidone has drawbacks such as hepatic first pass metabolism which is overcome by means of mouth dissolving film. In the present research, mouthdissolving films of riseperidone were developed using low viscosity grades of HPMC K15 and sorbitol polymers and propylene glycol as plasticizer and purified water as solvent followed by solvent casting method. All films prepared were smooth and elegant in appearance and showed no visible cracks; were uniform in thickness, weight and drug content.

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Keywords

Schizophrenia, Risperidone, mouth dissolving film, HPMC K15, Propylene glycol.

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