(3.239.33.139)
Users online: 2710    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 2918) Last page : ( 2921)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00538.3

In vitro Screening for Anti-Cholinesterase and Anti Oxidant Activity of Extract of Garcinia hanburyi

Dr. Chitra V.1,*, Narayanan J.2

1Research Scholar, SRM College of Pharmacy, Department of Pharmacology, SRM University, Kattankulathur, Tamil Nadu, India

2Vice Principal and Head, SRM College of Pharmacy, Department of Pharmacology, SRM University, Kattankulathur, TamilNadu, India

*Corresponding Author E-mail: akashnara07@gmail.com,velchitram74@gmail.com

Online published on 31 October, 2018.

Abstract

Garciniahanburyi belongs to the family Clusiaceae. The whole plant was dried, extracted to obtain Xanthone rich extract. Phytochemical studies of extract showed the presence of Phenols, Alkaloids, steroids, resins and saponins. Alzheimer's disease the most common form of dementia, a brain disorder which has been affecting the elderly. The natural sources such as a plants are an abundant source having various medicinal properties. In the present study, Garciniahanburyi has been selected to test for the AChE, BuChE activity by Ellman's method. The anti-oxidant activity has been performed by DPPH assay. The results showed that the extract from Garciniahanburyi could inhibit the activity of AchE and BuChE. It showed a significant % inhibition of AChE at 73.5% and BuChE inhibition of 57.5%. The IC50 values for DDPH scavenging activity was significant when compared with the standard Ascorbic acid.

Top

Keywords

Garciniahanburyi, Xanthones, Anti-cholinesterase, Anti-oxidant, Alzheimer's disease, Oxidative Stress.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
477,921,123 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.