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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 2768) Last page : ( 2775)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00512.7

In vivo Antioxidant and Modulating Enzymes of Wattakaka Volubilis and Kaempferol against Aluminium Sulphate Induced in Liver Toxicity

Usharani S*, Anuradha R.

PG and Research Department of Biochemistry, S.T.E.T.Women's College, Sundarakottai, Mannargudi–614001. Tamil Nadu, India

*Corresponding Author E-mail: usharani1886@gmail.com

Online published on 31 October, 2018.

Abstract

Objective

The In vivo antioxidant and modulating enzymes of the Wattakaka volubilis leaves and kaempferol against aluminium sulphate induced toxicity in rats.

Methods

Hepatotoxic rats were treated with methanol extract of Wattakaka volubilis and kaempferol for a period of 14 days.

Results

The activities of LPO, SOD, CAT, GSH, GR, GPx and membrane bound enzymes, Mitochondrial enzymes in liver. The activities of all parameters registered a significant (p≤0.001) alteration in aluminium sulphate treated rats, which were significantly recovered towards an almost normal level in rats co-administered with Wattakaka volubilis extract in a dose-dependent manner. All the biochemical investigations were confirmed by the observations and compared with the standard drug silymarin.

Conclusion

Antioxidant enzymes, membrane bound ATPase, mitochondrial TCA cycle enzymes enzymes modulated by kaempferol on aluminium sulphate induced liver toxicity.

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Keywords

Antioxidants, free radicals, hepatoprotection, Wattakaka volubilis, Mitochondrial enzymes, membrane bound enzymes.

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