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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 7
First page : ( 2765) Last page : ( 2767)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00511.5

Synthesis and Antimicrobial Evaluation of Some Novel Mercapto Pyrimidine via Pyrrole Chalcone

Kumar Pankaj1, Kumar Abhishek1,*, Nayak Prashant2, Geena3, Bhashini3

1Assistant Professor, Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences Paneer, Deralakatte, Mangalore, 575018, Karnataka, India

2Department of Pharmaceutics Nitte (Deemed to be University) Paneer, Deralakatte-575018, Mangalore, Karnataka

3NGSM Institute of Pharmaceutical Sciences Nitte (Deemed to be University) Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 31 October, 2018.

Abstract

In an effort to develop antimicrobial agents, a series of mercaptopyrimidines were prepared by condensation of appropriate 3 Acetyl-2,4-dimethyl pyrrole with appropriate aromatic aldehydes in the presence of H2SO4 at room temperature. The final synthesized mercapto pyrimidine derivatives is prepared by the cyclization of pyrrolylchalcones with thioureain presence of KOH as base The synthesized compounds were characterized by means of their IR, Mass 1H-NMR spectral data. All the compounds were tested for their antibacterial and antifungal activities by the cup plate.

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Keywords

3Acetyl-2,4-dimethyl pyrrole, Pyrrolylchalcones, Mercapto pyrimidine, Antibacterial.

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