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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2460) Last page : ( 2462)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00453.5

Synthesis and antimicrobial evaluation of some novel pyrazoline incorporated pyrrole derivatives

Kumar Pankaj1, Kumar Abhishek1,*, Nayak Prashant2, Pinto Jean Sandra3, D'Souza Brynish3

1Department of Pharmaceutical Chemistry, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

2Department of Pharmaceutics, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

3NGSM Institute of Pharmaceutical Sciences, Nitte University, Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 24 August, 2018.

Abstract

The synthesis and antimicrobial evaluation of some novel pyrazoline incorporated pyrrole derivatives has been presented. In this particular presentation novel substituted pyrazoline incorporated pyrrole derivatives (PKS3a-PKS3e) were synthesized by simple condensation reaction between different substituted aldehydes and 3 acetyl 2, 4-dimethyl pyrrole in presence of a strong ethanolic base to yield the pyrrolechalcones. The final synthesized pyrazolincompounds is prepared by the cyclization of pyrrolylchalcones with hydrazine hydratein presence of ethanol. The structures of the final synthesized compounds were characterized by IR, Mass and 1H NMR spectra. The synthesized compounds were screened for their antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosaby cup plate method. Most of the compounds exhibited promising antibacterial activity.

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Keywords

3 Acetyl-2, 4-dimethyl pyrrole, Pyrrolechalcones, pyrazoline, Antibacterial.

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