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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2301) Last page : ( 2305)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00426.2

Formulation and evaluation of immediate release tablet of risperidone

Deepika1, Alexander Amit1, Agrawal Palak1, Banjare Tripti1, Bhatt Aditi1, Gupta Swapnil1, Bhandarkar Akansha1, Sahu Hemlata1, Diwedi Shradha Devi1, Sahu Siddharth Kumar1, Yadav Pooja1, Sahu Kailash1, Dewangan Deeksha1, Thapa Hemlata1, Sahu Pankaj1, Soni Sonam1, Singh Ajay2, Sharma Mukesh1, Tripathi D. K.1, Ajazuddin1,*

1Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024

2GD Rungta College of Science and Technology, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024

*Corresponding Author E-mail: write2ajaz@gmail.com, ajazuddin@rungta.ac.in

Online published on 24 August, 2018.

Abstract

The main objective of the present investigation was to formulate Risperidone immediate release tablet. Risperidone, an antipsychotic drug mainly act as a D2 and 5HT2A receptor antagonist. Superdisintegrants agents like kollidon and citric acid were used and compressed into tablet by direct compression method. Risperidone is mainly used to treat schizophrenia bipolar disorder. The six formulations having different concentration of superdisintegrants were prepared and formulation blend was examined for angle of repose, bulk density tapped density and compressibility. The tablet were evaluated for various parameters like hardness, thickness, friability, weight variation, disintegration time and invitro dissolution time, all the parameter were found within limits.

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Keywords

Risperidone, Immediate release tablet, Superdisintegrants, In-Vitro Dissolution, UV spectrophotometer.

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