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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2217) Last page : ( 2219)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00410.9

Effect of LH/FSH ratio and its correlation with insulin resistance in PCOS obese woman of reproductive age group.

Revathi R1,*, Julius A2

1Ph. D., Research Scholar, Bharath University Selaiyur, Chennai

2Professor and Head, Department of Biochemistry, Sree Balaji Dental College, Bharath University, Pallikaranai, Chennai

*Corresponding Author E-mail: revathi_3aug@yahoo.co.in

Online published on 24 August, 2018.

Abstract

To study the effect of LH/FSH ratio and its correlation with insulin resistance in PCOS obese woman. The study includes 100 PCOS obese females of age 18–45 yrs. Further analysis revealed that the majority of obese PCOS woman shows abnormal LH/FSH ratio which correlate with insulin resistance compared to normal control subjects. In PCOS women, normal gonadotropin-ovarian axis is disturbed. This is reflected by the higher levels of LH, lower FSH levels and reversal of LH: FSH ratio. Further Insulin resistance perceived as the main cause for the development of PCOS.

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Keywords

LH (luteinizing hormone), FSH (follicle stimulating hormone), LH/FSH ratio, Homeostasis model assessment for insulin resistance (HOMAIR), polycystic ovary syndrome (PCOS).

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