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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2213) Last page : ( 2216)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00409.2

In Vitro cytotoxicity of L-Glutaminase against Hep-G2 cell lines

Unissa Rahamat*, Varma Devaragattu Bhargav**, Kesana Naga Santhosh***, Srinivas Chekalta****, Raj Baddanapally Shalem*****

Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad, Telangana, India

*Corresponding Author E-mail: srunissa@gmail.com,

**brudevaragattu@gmail.com,

***santhoshgtr35@gmail.com,

****chsrinivas998@gmail.com,

*****shalemrajbaddanapally@gmail.com.

Online published on 24 August, 2018.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common types of malignancies that carries poor prognosis worldwide. Accumulating evidences suggest the beneficial effects of amino acid-depleting enzymes in lowering the risk of various cancers. Herein, we investigated the in vitro antioxidant (DPPH) and anticancer effects of Lglutaminase produced by Idiomarina sediminum; H1695 against Hep-G2 cell lines by MTT assay. Collectively, these findings indicate a crucial role of L-glutaminase in liver cancer.

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Keywords

Hepatocellular carcinoma (HCC), Antioxidant, L-glutaminase, Hep-G2 cell line, 2, 2-diphenyl1-picrylhydrazyl (DPPH).

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