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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 6
First page : ( 2168) Last page : ( 2172)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00401.8

Increased platelet volume indices is associated with the severity of coronary artery disease

Alkhateeb Maya1,*, Kaddar Tagrid2

1Postgraduate Student, Department of Microbiology and Biochemistry, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

2Associate Professor, Department of Laboratory Medicine, Faculty of Medicine, Tishreen University, Lattakia, Syria

*Corresponding Author E-mail: maya931990@hotmail.com

Online published on 24 August, 2018.

Abstract

Platelets play key roles both in the pathogenesis of atherosclerosis and in the development of acute thrombotic events. Platelet size correlates with platelet activity and can be assessed by platelet volume indices, which are mean platelet volume (MPV), platelet distribution width (PDW), and Platelet-large cell ratio (P-LCR). We enrolled 101 patients with stable angina, unstable angina or myocardial infarction undergoing coronary angiography. Patients were divided into three groups according to their degree of stenosis and the number of stenotic vessels; Non-significant coronary artery disease (CAD) was defined as a stenosis <50% in coronary vessel, significant coronary artery disease was defined as a stenosis >50% in at least 1 coronary vessel, while severe coronary artery disease was defined as left main and/or three-vessel disease >50%. Blood samples were run through the automated blood analyzer to obtain the platelet indices. As a result, a statistically significant increase in all three platelet volume indices was observed in patients with severe CAD compared to those with non-significant CAD. We concluded that platelet volume indices, MPV, PDW, and P-LCR, are useful markers for the diagnosis of severe coronary artery disease.

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Keywords

Mean platelet volume (MPV), Platelet distribution width (PDW), Platelet-large cell ratio (P-LCR), Coronary artery disease, Atherosclerosis.

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