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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 2149) Last page : ( 2151)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00397.9

A review on the role of presenilin in alzheimer's disease

Aanandhi M. Vijey1,*, Kumar B Yeshwanth Prasanna2, Chowdary P Ranadheer3, Praveen D3

1Department of Pharmaceutical Chemistry and Analysis, School of Pharmaceutical Sciences, Vels University, (VISTAS), Chennai, India

2Department of Pharmacy Practice. School of Pharmaceutical Sciences, Vels University, (VISTAS), Chennai, India

3Research Scholar, School of Pharmaceutical Sciences, Vels University, (VISTAS), Chennai, India

*Corresponding Author E-mail: hodpchemistry@velsuniv.ac.in

Online published on 21 August, 2018.

Abstract

Alzheimer's disease (AD) is the most common form of dementia. It characterized by the presence of numerous senile plaques and neurofibrillary tangles in the cerebral cortex and hippocampus of affected individuals. Mutations in the genes encoding presenilin 1 (PSEN1), presenilin 2 (PSEN2), and amyloid precursor protein have been identified as the main genetic causes of familial AD. To date, more than 200 mutations have been described worldwide in PSEN1, which is highly homologous with PSEN2, while mutations in PSEN2 have been rarely reported. We performed a review of studies describing the mutations identified in PSEN1 and PSEN2. This article brings about the information pertaining to the role of presenilin and its derivatives in Alzheimer's disease.

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Keywords

Alzheimer's disease, Amyloid precursor protein, Mutation, presenilin 1, presenilin 2.

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