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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 5
First page : ( 2139) Last page : ( 2148)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00396.7

Analytical methods of ciprofloxacin and its combinations review

Kawas Ghoufran1, Marouf Mohammad1, Mansour Oussama1,*, Sakur Amir Alhaj1

Pharmaceutical Chemistry and Quality Control Dept Faculty of Pharmacy, Al Andalus University, Syria

1Dept. of Chemistry Faculty of Science, Tishreen University, Syria

*Corresponding Author E-mail: mansouroussama@yahoo.fr

Online published on 21 August, 2018.


Ciprofloxacin is a second generic and an antibiotic generic drug. It is a very popular fluoroquinolone that can treat a number of bacterial infections. The quinolones are family or a group that has activity against both-negative and positive-gram bacteria, when compared to Ciprofloxacin. The first aim of this review is to provide a comprehensive update of analytical methods for determining the Ciprofloxacin and its combinations, binary or triple mixture use of endodontic treatment of primary teeth using a combination of antibacterial drugs. The other aim of this review is to evaluate clinical and radiographic success of the endodontic treatment of infected primary teeth using a combination of ciprofloxacin, metronidazole, minocycline, and clindamycin. Several methods were used in the analytical determination of Ciprofloxacin and its metabolites in human biological fluids (plasma) and in pharmaceutical preparations. various techniques have been reported, such as UV, TLC, GC-Mass, HPLC and RP-HPLC methods, for the determination of Ciprofloxacin alone and in its combinations by high performance liquid chromatography and reversed phase-high performance liquid chromatography. This review provides details on separation conditions for Ciprofloxacin alone and its combinations.



Ciprofloxacin, separation techniques, Chromatography, HPLC, RP-HPLC, endodontic treatment.


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