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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 4
First page : ( 1307) Last page : ( 1312)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00243.3

Formulation and Evaluation of Ascorbic acid Lozenges for the treatment of Oral Ulcer

Bhandarkar Akansha, Alexander Amit, Bhatt Aditi, Sahu Pankaj, Agrawal Palak, Banjare Tripti, Gupta Swapnil, Sahu Hemlata, Diwedi Shradha Devi, Sahu Siddharth Kumar, Yadav Pooja, Sahu Kailash, Dewangan Deeksha, Thapa Hemlata,  Deepika, Verma Vinay Sagar, Sharma Mukesh, Tripathi D. K.,  Ajazuddin*

Rungta College of Pharmaceutical Sciences and Research, Kohka-kurud Road, Bhilai, Chhattisgarh, 4900024

*Corresponding Author E-mail: write2ajaz@gmail.com; ajazuddin@rungta.ac.in

Online published on 24 July, 2018.

Abstract

Inspite of several dosage forms available in the market for effective localized action, the lozenges finds a special importance, as they are the best dosage forms for formulating large dose medicaments. The anatomy of mouth and cheek favors easy absorption of drug, reducing the systemic absorption thus ensuring a better patient compliance especially for pediatrics and geriatrics. Ascorbic acid mechanism of action suites this type of formulation and easily absorbed in oral cavity. Preformulation studies are primarily done to investigate the physicochemical properties of drug and to establish its compatibility with other excipients. Ascorbic acid was mixed with all excipients, used in the formulation in different. The formulated lozenges were evaluated for physical parameters and the results complied with the pharmacopoeiallimits.ascorbic acid hard candy lozenges were prepared by heat fusion method using sugar as a base. The usage of corn syrup in the formulation made the lozenges transparent and smooth, which helped in improving the elegancy of formulation. The controlled release of medicament from Lozenges was achieved by using polymers like methyl cellulose, locust bean gum, HPMC, K4M and xanthan gum. The prepared lozenges were subjected to physico-chemical as well as in vitro drug release study. Among all the formulations of hard candy lozenges FL1 showed good stability.

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Keywords

Hard candy lozenges, Ascorbic acid, Lozenges, methylcellulose, mouth ulcers, xanthan gum, In-process testing, batch process testing.

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