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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 3
First page : ( 1251) Last page : ( 1254)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00233.0

Role of Bone Morphogenic Protein 3 in the regulation of Bone Growth and Development

DR. Kumar M. P. Santhosh1,*,  Devishree2

1Reader, Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University, 162, Poonamallee High Road, Velappanchavadi, Chennai, 600077, Tamil Nadu, India

2Undergraduate Student, Department of Oral and Maxillofacial Surgery, Saveetha Dental College, Saveetha University

*Corresponding Author E-mail: santhoshsurgeon@gmail.com

Online published on 7 July, 2018.

Abstract

Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-β (TGF-β) super family. BMP3 was originally purified from bone as osteogenin, which induces osteogenic differentiation. Bone morphogenic protein 3 inhibits osteoblast differentiation and is thus a negative regulator of bone density. Bone morphogenic protein 3 plays a role in fracture healing, mechanical loading of the skeleton, development, and osteoporosis. This article reviews the various functions of bone morphogenic protein 3 and its clinical applications.

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Keywords

Bone morphogenic protein 3, BMP 3, bone formation, cartilage, protein, receptor, fracture healing.

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