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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 3
First page : ( 1017) Last page : ( 1022)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00190.7

Preparation and Evaluation of Nateglinide-Cyclodextrin Inclusion Complex

 Venkatesh1, Kumar Anand Y2,*, Setty C. Mallikarjuna3

1Department of Pharmaceutics, Sarada Vilas College of Pharmacy, Mysore, India

2Department of Pharmaceutics, V.L. College of Pharmacy, Raichur, India

3Oxford College of Pharmacy, Bengaluru, India

*Corresponding Author E-mail: neeru241586@yahoo.co.in

Online published on 7 July, 2018.

Abstract

A physicochemical characterization of nateglinide (NT)-hydroxy propyl β-cyclodextrin (HPβCD) inclusion complex both in solution state and solid state were studied to improve the solubility and dissolution properties of nateglinide. Inclusion complex were prepared by micro wave irradiation and kneading method at 1: 1M, 1: 2M ratios. The prepared inclusion complex were investigated in solution state by drug content, phase solubility studies and solid state by differential scanning calorimetry (DSC), Fourier transformation-infrared spectroscopy (FTIR), X-ray diffractometry (XRD) and in vitro dissolution studies. Phase solubility studies revealed 1: 1M stoichiometry inclusion complex, a true inclusion complex was observed at 1: 1 and 1: 2M ratios it was confirmed by FTIR, DSC, XRD studies. In vitro dissolution data suggests the dissolution properties of nateglinide was dependent on method and ratio, the inclusion complex of both methods shows superior dissolution properties when compare to corresponding physical mixture and pure nateglinide.

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Keywords

Nateglinide, HPβCD, FTIR, DSC, XRD, in vitro dissolution.

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