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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 2
First page : ( 723) Last page : ( 729)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00136.1

Analytical Spectrophotometric Study of Enalapril Maleate in Raw Material and Tablets Formulations

Antakli Saad*, Nejem Leon, Khoja Rayyan

Department of Chemistry, Faculty of Science, University of Aleppo, Syria

*Corresponding Author E-mail: antakli@scs-net.org

Online published on 12 June, 2018.

Abstract

Spectrophotometric method was developed and applied for the determination of enalapril maleate (ENP) in raw material and tablets formulations. This new method was applied to determine (ENP) in several Syrian trademark drugs such as: Enapril and Noropresh. Spectrophotometric method depended on reducing iron III to iron II by (ENP), which reacted with 1–10 phenanthrolin to form iron II: 1–10 phenanthrolin complex. This complex was determined at maximum wavelength 510 nm. Linearity range was to be between 10–90 μg/mL. Regression analysis showed a good correlation coefficient R2 = 0.9993. The limit of detection (LOD) and limit of quantification (LOQ) were 1.78 and 5.40 μg/mL respectively. The proposed method was successfully applied to analysis of (ENP) in Syrian trademark drugs. All studied samples showed that the drug levels were conformed to United state pharmacopeia (USP) legislation.

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Keywords

Enalapril Maleate, Spectrophotometric method.

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