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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 2
First page : ( 705) Last page : ( 710)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00133.6

Compartment Between Breast Cancer Patient Undergoing Chemotherapy and Healthy Women by Cytokinesis-block Micronucleus testand Nuclear Division Index

Kadhem Sara jawad1,*, Dr. Ali Abdul Sahib K.2, AL_rikabi Abdul-Ameer N.1

1Department of Biology, College of Science, AlMustansiriyah University, Baghdad, Iraq

2Ministry of Science and Technology, Central Laboratories Directorate, Baghdad, Iraq

*Corresponding Author E-mail: sarajoad14@gmail.com

Online published on 12 June, 2018.

Abstract

One of tests to measurement the effect for toxogintic material or some drugson chromosomes like chemotherapy or radiotherapy are micronucleus test (MNT) and nuclear division index (NDI), MNT and NDI easy tests and rapidly so in this study comparing between healthy women and breast cancer patients undergoing chemotherapy by notice the number of MN cell in peripheral lymphocytes and NDI to know chemotherapy effect on patient's chromosomes. high frequency of MN in breast cancer noticed from than control and less of NDI frequency in breast cancer from than control, this result happened because the effect of chemotherapy on chromosomes and broken it so the MN increased and and made it appear, chemotherapy made cell division decreased and cell death and necrosis increased.

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Keywords

Micronucleus test (MNT), nuclear division index(NDI), breast cancer (BC), peripheral blood lymphocytes (PBL).

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