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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 2
First page : ( 681) Last page : ( 686)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00128.2

Protective effect of Zanthoxylum armatum fruit on Heart Mitochondrial Antioxidants Against Isoproterenol Induced Cardiac Damage in Rats

Mangalanathan Malathi1, Uthamaramasamy Saraswathi1,*, Venkateswaran Ramalingam2

1Department of Biochemistry, Department of Chemistry, PSG College of Arts & Science, Coimbatore, 641014, Tamilnadu, India

2PSG College of Arts & Science, Coimbatore, 641014, Tamilnadu, India

*Corresponding Author E-mail: sarasbiochem@yahoo.co.in

Online published on 12 June, 2018.

Abstract

Background

Mitochondria are prone to oxidative stress induced by chemicals and resulting in cardiac damage which can be ameliorated by the use of herbal drugs. Zanthoxylum armatum (Z. armatum) fruit are used as ageold herbal remedies. Their pharmacological and therapeutics actions are not exploited in detail.

Objective

The present study is to analyze the antioxidants in the heart mitochondria of the rats challenged with isoproterenol hydrochloride (ISO) and the ameliorative effect of Z. armatum fruit.

Method

The antioxidant effect of hydroethanolic extract of Z. armatum fruit on mitochondrial dysfunction induced by ISO in rats were appraised by studying the antioxidant enzymes namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione S-transferase (GST) and lipid peroxidation (LPO) in mitochondrial fractions.

Results

Pretreatment with Z. armatum fruit at two different concentrations (200mg, 400mg/kg body weight) not only increased the activities of endogenous antioxidant enzymes (SOD, CAT, GPx, GST) and reduced glutathione (GSH) but also decreased the level of LPO in myocardial infarction (MI) induced rat heart mitochondria exposed to ISO.

Conclusion

The enhanced antioxidant activity of Z. armatum fruit protected the heart mitochondria in rats against ISO-induced damage. This study may have a significant impact on the diseases that is caused by free radicals and the role of antioxidants in averting the diseases.

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Keywords

Zanthoxulym armatum fruit; mitochondrial antioxidants; Isoproterenol hydrochloride; Free radicals.

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