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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 2
First page : ( 667) Last page : ( 670)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00125.7

Tea Poly Phenol-Zinc Oxide nano Particle effects on Infertile Smoker's Spermatozoa-A Short Report

Balasundaram Sridharan1,*, Ranganathan Parameswari2, Rao Kamini A3

1Plant Biotechnology Lab, (National Tea Research Foundation Scheme), VIT University, Vellore, Tamil Nadu, India

2Gene Cloning and Technology Lab, Department of Bio Medical Sciences and Technology, VIT University, Vellore, Tamil Nadu, India

3Andrology Unit ART Medicine, Milann Hospital, Bangalore, Karnataka, India

*Corresponding Author E-mail: tbsridharan@vit.ac.in

Online published on 12 June, 2018.

Abstract

Objective

To evaluate the TPP-ZnO nano particle cyto toxic activity against smoking influenced spermatozoa

Design

An experimental study

Setting

Gene Cloning and Technology Lab, VIT University, Vellore

Patient(s)

Chronic smokers who came for first time for infertility issues

Intervention(s)

Tea poly phenol (TPP) mixed zinc oxide nanoparticle with smoker's semen against untreated control was analyzed.

Main Outcome Measure(s)

Spermatozoa motility, viability and appearance of morphology.

Result(s)

TPP mixed ZnO nano particle will give maximum (5%) of motility and MTT-IC50 shows the maximum viability (P<0.001) with positive morphological changes which near to untreated control.

Conclusion(s)

Metal toxicity from smoking effect on sperm motility and viability was reduced or improved with another natural antioxidant of TPP through ZnO nano delivery

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Keywords

Zinc oxide nano particle, Smoking, Cadmium, Tea poly phenol, ROS.

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