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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 2
First page : ( 527) Last page : ( 531)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00098.7

Gastro Protective effect of Standardized Ethanolic leaf extract of Indigofera tinctoriao on experimental Gastric Ulcers in Rats

Manimekalai P.*, Maheshwari P., Velmurugan R., Gurumoorthy M., Kumar S. Hansraj, Vijayakumar G.

Department of Pharmacology, School of Pharmaceutical Sciences, Vels University, (VISTAS), Pallavaram, Chennai-600117, Tamilnadu, India

*Corresponding Author E-mail: mekalaivel@gmail.com

Online published on 12 June, 2018.

Abstract

Objective

The anti-ulcer activity of ethanolic extract of Indigofera tinctoria (Fabaceae) leaf (EEIT) was investigated in Indomethacin and ethanol induced ulcer models in wistar rats.

Methods

The preliminary Phytochemical evaluation was carried out by standard methods. Indomethacin and ethanol induced ulcer models the common parameter determined was ulcer index. Animals are divided in to four groups. First groups serves as control, second group treated with standard drug third and fourth group treated with EEIT at doses of 200 and 400 mg/kg p.o produced significant inhibition of the gastric lesions induced by Indomethocin induced ulcer and Ethanol induced gastric ulcer.

Results

Phytochemical evaluation shows that alkaloids and flavonoids are present in extract. The extract (200 mg/kg and 400 mg/kg) showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that Indigofera tinctoria extract have potential anti ulcer activity in the both models. Cellular level changes was reveled with histopathological studies.

Conclusion

These results may further suggest that ethanolic extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.

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Keywords

Indigofera tinctoria, Indomethacin, Ethanol induced ulcer model, ulcer index.

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