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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5599) Last page : ( 5610)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.01018.1

Formulation and Evaluation of Domperidone Sustained Release Tablet

Khan Wasim1,*, Siddique Noor Fatima2, Siddiqui Javed1, Dr. Hussain Zeashan1, Farooqui Sana1

1Mahatma Gandhi Institute of Pharmacy, Lucknow, UP

2Babasaheb Bhimroa Ambedkar University, Lucknow, UP

*Corresponding Author E-mail: 92wasimkhan@gmail.com

Online published on 18 May, 2019.


In present study, an attempt has been made to design and develop Domperidone matrix tablets using Hydroxypropyl methylcellulose K100M, 5CPS and combination with Acrypol as release retarding polymers by wet granulation method. Domperidone is a peripheral dopamine receptor with blocking properties. Domperidone helps in the gastric emptying and decreases small bowel passing time by increasing esophageal and gastric peristalsis and also by lowering esophageal sphincter pressure. Domperidone sustained release matrix tablet were prepared and evaluated for number of parameters like thickness, diameter, weight variation, swelling index and in vitro release studies. The weights of the tablets were in the range of 125 ± 2 mg. The thickness of the tablet was in the range of 3.25± 0.2 to 3.27 ± 0.2 mm. FT-IR spectral analysis showed that characteristic peak of Domperidone pure drug was retained in the spectra of all the formulations corresponds to the compactness of the drug in all the formulations. The result indicates that Hydroxypropyl Methylcellulose K100M and Acrypol 974p in combination and individual Hydroxy Propyl Methyl Cellulose-5CPS respectively and can be used as an effective matrix former to sustain the release of Domperidone for an extended period of 10 hrs.



Matrix tablet, wet granulation, sustain release, polymers.


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