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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5474) Last page : ( 5482)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00998.8

Ophthalmic Microemulsion: Formulation Design and Process Optimization

Bodkhe Atul Arvind1,*, Bedi Ramandeep Singh1, Dr. Upadhayay Ashutosh1, Dr. Kale Mohan K.2

1Department of Pharmacy, Faculty of Allied Health Sciences, Mahatma Jyoti Rao Phoole University, Achrol, Jaipur, India

2Konkan Gyanpeeth Rahul Dharkar College of Pharmacy and Research Institute, Ladiwali Village, Karjat, Maharashtra, 410201

*Corresponding Author E-mail: atul.bodkhe@gmail.com

Online published on 18 May, 2019.

Abstract

The microemulsion systems, o/w, composed of castor oil, sesame oil, arachis oil, olive oil, polysorbate 20, polysorbate 80, Tyloxapol, Carbomer 974P, carboxymethyl cellulose sodium, hydroexthylecellulose, glycerine, propylene glycol, sodium chloride and purified water, taken at various amounts and in various combinations, were tested in order to assess their physical-chemical compatibility. All ingredients of the microemulsions were physiologically acceptable. Microemulsions were evaluated for the different parameters to access the effect of processing parameters on the globule size formation and stability. The stable microemulsion system was obtained for the formulation in which castor oil and polysorbate 80 was used. The following parameters were analyzed: description, pH, osmolality, viscosity, specific gravity, globule size, polydispersity index (PDI) zeta potential, surface tension, assay, in vitro Drug Release. The study made it possible to select the most stable microemulsion system meeting the requirements of eye drops. Thus, the proposed formulation and process were successfully developed and evaluated.

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Keywords

Microemulsion, Surfactant, Drug solubilizing agent, Homogenization, globule size.

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