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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5408) Last page : ( 5412)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00987.3

Synthesis and Antioxidant Activity of Some New Coumarin Incorporated 4-Thiazolidinone Derivatives

Bhat K. Ishwar, Apoorva A, Kumar Abhishek*, Kumar Pankaj

Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical Sciences, NITTE (Deemed to be University), Paneer, Deralakatte-575018, Mangalore, Karnataka

*Corresponding Author E-mail: abhi12bunty@gmail.com

Online published on 18 May, 2019.

Abstract

A series of new 4-thiazolidinone derivatives were synthesized by reacting various coumarinyl schiff bases with thioglycollic acid. The intermediate coumarinyl schiff bases were synthesized by reacting 4-hydroxyl coumarin with various substituted anilines in alcohol medium. All the newly synthesized compounds were assigned on the basis of IR, 1H NMR and mass spectral data. All the newly synthesized compounds were evaluated for in-vitro antioxidant activities like DPPH, nitric oxide and hydrogen peroxide radical scavenging assay models. Most of the synthesised compounds showed good antioxidant activity.

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Keywords

Coumarins, Thiazolidinones, Antioxidant activity.

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