Synthesis, Medicinal Applications and QSAR Study of Benzimidazole, Thiophene, Piperazine derivatives for Antimycobacterial, Antibacterial, Antifungal Activities
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Benzimidazole, Thiophene, Piperazine derivatives regarded as an important heterocyclic motif that exhibits a wide range of Medicinal applications including Antimycobaterial, antibacterial, Antifungal, Anti-HIV's. In the view of their wide ranging activities the synthesis of benzimidazole, Thiophene, Piperazine and its derivatives remain a primary focus for synthetic chemistry Communities. The association of HIV and TB infection is a serious problem. TB is caused by bacilli belonging to the Mycobacterium tuberculosis. In the Review of Literature it was observed that various method's are available for synthesis of Benzimidazole, Thiophene, piperazine derivatives. Thirty seven compounds were synthesized and the structures of these compounds were established by means of IR, 1H-NMR, C13 NMR and elemental analysis. All compounds were evaluated for antibacterial, antifungal and antitubercular activities. Most of the compounds have shown significant antibacterial, antifungal and antitubercular activity when compared with the standard drug. QSAR Study will be done as per the need of Compound.
Benzimidazole, Piperazine, Thiophene, QSAR, TB.