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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 12
First page : ( 5313) Last page : ( 5318)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00967.8

Formulation and Evaluation of Pioglitazone HCl Fast Dissolving Tablet using Solid Dispersion

Yadav Pinky*, Patel Pankaj, Das Prabhat, Deshmukh Nitin, Dr. Pillai Sujit

Dept. of Pharmaceutics, GRY Institute of Pharmacy, Borawan, Khargone (M.P)

*Corresponding Author E-mail: kumar_prabhat3027@yahoo.com

Online published on 18 May, 2019.

Abstract

Pioglitazone HCL is a BCS class-II (poorly water soluble) drug and its absorption is dissolution rate limited. The solubility and the dissolution rate of the drug was enhanced by using the solid dispersion technique. The main purpose of this investigation was to increase the solubility and dissolution rate of pioglitazone HCL by the preparation of its solid dispersion with PEG-6000 using solvent evaporation methods. FT-IR spectra revealed no chemical incompatibility between drug and PEG-6000. The result obtained show that the dissolution profile of pioglitazone HCL solid dispersion was considerably improved. The dissolution profile solid dispersion formulation SD1 contains (1: 1) (drug: polymer) formulation SD2 (1: 2) & formulation SD3 (1: 3) was found to be 97.83±0.09, 94.03±0.09, 91.26±0.03 respectively. Based on the above dissolution data SD1 is found to be best as a solid dispersion for fast dissolving tablet. Based on the result solid dispersion technique can be an acceptable method for improving the dissolution profile of poorly aqueous soluble drug.

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Keywords

Pioglitazone HCL, Fast dissolving tablet, Solid dispersion, PEG-6000, Solvent Evaporation Method.

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