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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 11
First page : ( 5037) Last page : ( 5041)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00918.6

Evaluation of Hypolipidemic Potential of a Polyherbal Formulation in Experimental Rats

Jaybhaye Manoj1,*, Jagtap Pradnya1, Unadle Vaishali1, Shinde Sachin2, Bhagvat Gajanan3, Porwal Ashwin3, Jagtap Vishakha1

1Department of Pharmacology, S.G.R.S. College of Pharmacy Saswad, Pune

2Shri. R. D. Bhakt College of Pharmacy, Jalna, Maharashtra, India

3Helling Hand Herbs, Tilak Road, Pune

*Corresponding Author E-mail: manojjaybhaye@gmail.com

Online published on 30 January, 2019.

Abstract

In present investigation we evaluated of hypolipidemic potential of a Polyherbal formulation in High cholesterol containing diet induced hyperlipidemia in experimental rats. Hyperlipidemia was induced in 18 rats. HCCD were given orally to induce Hyperlipidemia. HCCD given to all rat except normal group upto 10 days. Hyperlipidemia was confirmed on 10th day by evaluating blood glucose level. Orally administered atervastatin at 1.2 mg/kg/per day served as a standard. Polyherbal formulation (LC-01) was given orally at 500 mg/kg daily to rats for 28 days, and body weight as well as blood glucose, total cholesterol, triglyceride, HDL cholesterol levels were determined at 7 days intervals and compared with those of control and standard groups. LC-01 treated rat's shows normal gain in body weight as compared to DC group. DC groups showed significantly increased level of blood glucose, total cholesterol, triglycerides and a higher level of HDL cholesterol. The group that received the polyherbal formulation had significantly reduced levels of serum blood glucose, total cholesterol, triglycerides and a higher level of HDL cholesterol. The polyherbal formulation exerts antihyperlipidemic and anti-obesity activities comparable to those of a modern lipid-lowering agent (atorvastatin) in rats.

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Keywords

Obesity, Lipid profile, Polyherbal formulation, Hyperlipidemic, HDL.

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