(3.238.95.208)
Users online: 2373    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 11
First page : ( 4888) Last page : ( 4891)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00890.9

Terminalia chebula Retz improve memory and learning in Alzheimer's Model: (Experimental Study in Rat)

Lakshmi K.*, Karishma S. K., Chandra Sekhar G.N.S.S., Babu A. Narendra, Kumar N. Bhargav

Chalapathi Institute of Pharmaceutical Sciences, Lam, Guntur-522 034, Andhra Pradesh, India

*Corresponding Author E-mail: lakshmikakunuri95@gmail.com

Online published on 30 January, 2019.

Abstract

Objective

The aim of this study was to identify the potential of Terminalia chebula as a protective and therapeutic agent against Alzheimer's disease.

Methods

The learning and memory enhancing activity of Terminalia chebula fruit extracts were investigated in rats by using the ethanol-induced cognitive impairment and diazepam induced amnesia and its effects on learning and memory were examined by using Morris water maze (MWM) test.

Results

All the groups showed significantly (P value is<0.01 and <0.05) decrease transfer latency at all periods as compared to ethanol and diazepam inducing group. Therefore Fruit extracts of Terminalia chebula exhibited significant learning and memory activity in Alzheimer's disease.

Conclusion

The present study suggests Terminalia chebula that modulate the oxidative stress and be involved in the protective effect against oxidative damage and neurodegenerative diseases in rat.

Top

Keywords

Ethanol, diazepam, Morris water maze, learning and memory activity, Alzheimer's disease.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
514,084,307 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.