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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 10
First page : ( 4675) Last page : ( 4678)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00855.7

Determination of Some Types of Mutations in Iraqi Transfusion Dependent beta-thalassemia Patients

Dr. AL-Shimaysawee Sadeq*

Faculty of Pharmacy, University of Kufa, Iraq

*Corresponding Author E-mail: sadeqh.musa@uokufa.edu.iq

Online published on 20 December, 2018.

Abstract

One hundred of beta thalassemia major patient's blood samples were collected in the Center Blood Diseases of Babylon hospital for Children and Maternity in Al-Hilla city. All samples of blood weresubjected to DNA isolation and molecular characterization of three beta-thalassemia mutations {IVS 1–110 (G-A)Fr16 and cod 8\9} using a PCR-ARMS technique. The Resultsshow that IVS1–110 mutation was the most common in the samples of patients as (22%)followed by Fr16 and Cod 8/9 were also detected but of lower percentage (8% and 3%, respectively).

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Keywords

Thalassemia, globin, mutation, .

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