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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 10
First page : ( 4605) Last page : ( 4612)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00843.0

Preparation, characterization and pH responsive delivery of Lenalidomide conjugated Fe3O4 nanoparticles

Sundararajan Raja*, Mallina Sri Anusha

Department of Pharmaceutical Analysis & Quality Assurance, GITAM Institute of Pharmacy, GITAM (Deemed to be University), Visakhapatnam, Andhra Pradesh, India-Pincode-530 045

*Corresponding Author E-mail: sraja61@gmail.com

Online published on 20 December, 2018.

Abstract

Selective administration of cancer drugs in a specific manner with respect to the physiological need at the tumor site can increase the efficiency of drugs and reduce side effects. Herein, developed a formulation, comprising of anti-cancer drug Lenalidomide conjugated to chitosan (Chs) coated iron oxide nanoparticles (Fe3O4-Chs) via a pH sensitive imine bond formation which enables active topical drug delivery in response to intra cellular pH change was demonstrated for potential treatment of cancer. The particle size was found to be around 40 (mean± SD (n = 20)) nm. The structural characterization of the synthesized formulation was done by X-ray diffraction, thermo gravimetric analysis, differential scanning calorimetry, Fourier transform infrared spectroscopy, vibrating sample magnetometer and transmission electron microscopy techniques. Therapeutic efficacy of Fe3O4-Lnd nanoparticles (Nps) was carried out in human breast cancer cells (MCF7) and human ovarian cells (SK-OV-3) by MTT assay which showed improved therapeutic efficacy of Lnd with Fe3O4-Lnd nanoparticles compared to free Lnd

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Keywords

Iron oxide nanoparticles, Chitosan, pH dependent, conjugation, targeted drug delivery.

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