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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 10
First page : ( 4569) Last page : ( 4574)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00836.3

Extraction, separation and characterization of bioactive compounds produced by Streptomyces isolated from vermicast soil

Balachandar R.1,*, Karmegam N.2, Subbaiya R.3

1Research Scholar, Faculty of Bioengineering, Sathyabama Institute of Science and Technology, Rajiv Gandhi Salai, Chennai-600 119, Tamil Nadu, India

2Department of Botany, Government Arts College, Salem-636 007, Tamil Nadu, India

3Associate Professor, Department of Biotechnology, Vinayaka Mission's Research Foundation, Aarupadi Veedu Institute of Technology, Paiyanoor, Chennai-600 128, Tamil Nadu, India

*Corresponding Author E-mail:

Online published on 20 December, 2018.

Abstract

This present study was Aimed to investigate identification of potent actinomycetes that have the ability to produce bioactive compounds was isolated from the vermicast soil collected from Sirumali Hills South India. The ethyl acetate extraction of isolated Streptomyces showed high biological activity against human pathogens. The crude ethyl acetate extract was subjected to TLC to separate compounds. GC-MS and FTIR analaysis were carried out to reveal the structural elucidation of isolated compounds. The identification of bioactive compounds is based on the peak area and retention time. GC-MS chromatogram of extract showed the presence of six bioactive compounds, including saturated and unsaturated fatty acids. The antagonistic activity of Streptomyces sample might be due to the synergistic effect of the identified compounds.

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Keywords

Actionmycetes, vermicast, GC-MS, Bioactive compounds, Ethyl acetate extract.

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