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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 1
First page : ( 328) Last page : ( 336)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00060.4

Freeze Dried Fenugreek Seed Mucilage as disintegrant for Fast Dissolving Tablets of Valsartan

Hajare Ashok A.1,*, Kale Sumedha N.1, Powar Trupti A.1

Bharati Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, 416 013, India

1Department of Pharmaceutical Technology, Bharati Vidyapeeth College of Pharmacy, Kolhapur-416 013, Maharashtra, India

*Corresponding Author E-mail: ashok.hajare@bharatividyapeeth.edu

Online published on 12 June, 2018.

Abstract

The objective of the research work was to formulate fast dissolving tablet of valsartan using freeze-dried fenugreek seed mucilage as disintegrant. An attempt was made to extract the mucilage from fenugreek seeds and Ocimum tenuiflorum linn seeds and was evaluated for its various physicochemical characteristics. Fast dissolving tablets of valsartan was formulated by direct compression using different concentrations of fenugreek gum and Ocimum tenuiflorum gum as a natural superdisintegrants and compared with synthetic superdisintegrants like crospovidone. The tablets formulated using fenugreek gum and Ocimum tenuiflorum were evaluated for various physical tests like friability, weight variation, hardness. In vitro dissolution study showed 93.32% and 91.46% drug release, 42, and 53 seconds disintegration time, respectively for fenugreek and Ocimum tenuiflorum gum tablets. Natural gums like fenugreek and Ocimum tenuiflorum have better disintegration properties with improved disintegration time, when used in combination with synthetic disintegrants.

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Keywords

Fast dissolving tablet, valsartan, freeze-dried natural disintegrants.

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