Synthesis, Characterization of New1, 3, 4-thiadiazole Derivatives with Studying their Biological Activity
In this work, thiadiazole derivatives were prepared by taking advantage of active sites in (2-amino-5-mercapto1, 3, 4-thiadiazole) as base. The main hetrocyclic compounds (1, 3, 4-thiadiazole, oxazole) etc. 2-amino-5mercapto-1, 3, 4-thiadiazole compound  was prepared by cyclic closure of thiosemicarbazide compound with anhydrous sodium carbonate and carbon disulfide. Oxidation of  via hydrogen peroxide, to have  which was treat with chloro acetyl chloride to get . Preparation of oxazole ring  obtained from reacting of  with urea. Schiff bases [5–7] prepared by reacting  with different benzyl aldehyde. And Preparation of derivative [8–11], from reaction  with of hydrazine derivatives. Full characterization of the synthesized compounds was done by using of spectroscopic analysis such as FT-IR, 1H-NMR and C.H.N.S,
1, 3, 4-thiadiazole, oxazole, thiosemicarbazide, Schiff bases.