(3.237.94.109)
Users online: 3014    [ij] [ij] [ij] 
Email id
 

Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 1
First page : ( 221) Last page : ( 226)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00041.0

Synthesis, Characterization and Biological Evaluation of Benzimidazole Derivatives as Potential Anxiolytics

Dokuparthi Sudheer K1,*, Naik J. Baloji1, Kumar K. Sunil1, Saidulu A.2

1Vijaya College of Pharmacy, Hyderabad-501511, India

2Department of Botany, Osmania University, Hyderabad, India

*Corresponding Author E-mail: skdokuparthi@gmail.com

Online published on 12 June, 2018.

Abstract

Considerable attention has been focused on the synthesis of benzimidazoles due to their broad spectrum of biological activities such as antimicrobial, anti diabetic, anti cancer, anti hypertensive, anti anxiolytic and inflammatory activities etc. As a part of our research work, a series of benzimidazole derivatives were synthesized in good to high yields by reaction of o-phenylenediamine and different aromatic aldehydes in the presence of ammonium chloride (NH4Cl), as an efficient catalyst at room temperature. This environmentally safe and practical method offers several advantages, such as high yields, use of an available catalyst, mild reaction conditions and easy work-up process. All synthesized compounds were characterized by detailed spectral analysis by using LC-MS, IR, and NMR spectroscopy. The synthesized benzimidazoles were screened for chronic anti anxiety activity in albino rats by using light and dark box model with standard Buspirone. Behavioral parameters were recorded during the test session of 5 minutes. All benzimidazole derivatives have shown significant anti anxiety activity compared to the standard. However, benzimidazole analog (3e) exhibited highest anxiolytic action.

Top

Keywords

Aromatic aldehydes, Ammonium Chloride, o-Phenylenediamine, room temperature, light and dark box apparatus, buspirone.

Top

  
║ Site map ║ Privacy Policy ║ Copyright ║ Terms & Conditions ║ Page Rank Tool
446,903,774 visitor(s) since 30th May, 2005.
All rights reserved. Site designed and maintained by DIVA ENTERPRISES PVT. LTD..
Note: Please use Internet Explorer (6.0 or above). Some functionalities may not work in other browsers.