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Research Journal of Pharmacy and Technology
Year : 2018, Volume : 11, Issue : 1
First page : ( 1) Last page : ( 8)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2018.00001.X

Formulation and Evaluation of Buccal Tablets of Diclofenac Sodium using Semi-Synthetic Polymers

Ranganathan Venkatalakshmi*, Hui Tan Siew, Sri Prasanthi

Faculty of Pharmacy, Department of Dosage Form Design, MASHA University-Jalan SP 2, Bandar Saujana Putra, 42610, Jenjarom, Selangor, Malaysia

*Corresponding Author E-mail: lakshmi@mahsa.edu.my

Online published on 12 June, 2018.

Abstract

The purpose of this research work is to formulate and evaluate diclofenac sodium buccal tablets using semisynthetic polymers such as hydroxypropyl methyl cellulose K4M (HPMC K4M), methyl cellulose (MC) and sodium carboxyl methyl cellulose (SCMC) along with ethyl cellulose (EC) as the backing membrane. The drug excipient compatibility study was carried out by Fourier transform infrared spectroscopy. The diclofenac sodium buccal tablets were formulated by direct compression method. The prepared diclofenac sodium buccal tablet were evaluated for general appearance, hardness, weight variation, thickness, swelling studies, drug content, friability test, in vitro disintegration test, in vitro dissolution test, in vitro drug release kinetic and ex vivo residence time.

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Keywords

Diclofenac sodium, buccal tablet, semi-synthetic polymers, direct compression, ex vivo residence time.

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