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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 9
First page : ( 3011) Last page : ( 3014)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00533.9

Molecular Docking and in vitro-Anti-Inflammatory evaluation of Novel Isochromen-1-one Analogues Frometodolac

Napoleon Ayyakannu Arumugam*, Sharma Vijay

Pharmaceutical Chemistry Laboratory SAS, VIT University, Vellore-632014, Tamil Nadu, India

*Corresponding Author E-mail: aanapoleon@vit.ac.in, napoleonaa@gmail.com

Online published on 16 May, 2018.


In the present work, the three synthesizedisochromen-1-one, their thio and N-methylated analogues derived from the anti-inflammatory drug Etodolacare assessed for its in-vitro anti-inflammatory activity and carried out molecular docking studies. Docking study result shows that compound, 5 possess good binding affinity with the COX-1 receptor showing a docking score of-8.2 and lipophilic interaction of-2.5 which is greater when compared to standard drugs such as Etodolac, Aceclofenac and Diclofenac were used. The same compound 5 also shows comparable in-vitroanti-inflammatory activity with etodolac as standard in both the methods screened.



Molecular docking, Isochromen-1-one, Etodolac, Isochromen-1-oneanalogues, Antiinflammatory activity.


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