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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 9
First page : ( 3003) Last page : ( 3010)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00532.7

Hormone Receptor Status and its Relation to C-Reactive Protein and other Prognostic factors in Breast Cancer in Jableh-Syria

Asaad Remal Abdulaziz*

Assistant Professor, Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria

*Corresponding Author E-mail: r_asaad2002@yahoo.fr

Online published on 16 May, 2018.

Abstract

Background

Breast cancer is the most common form of cancer among women worldwide, with the increase incidence and its associated morbidity, mortality, and enormous treatment costs, there is a great interest in strategies of prevention and detection of early prognostic factors. Serum CRP levels could be a marker of increased risk for breast cancer.

Aim of the study

Evaluation of estrogen-receptor ER, progesterone-receptor PR and human epidermal growth factor receptor 2 Her-2 expression in 60 female-patients of breast cancer in Jableh-Syria, and studying their relation with serum CRP levels and other prognostic factors.

Patients and methods

60 female-patients of breast cancer aged between 32 to 77 years old, admitted in National hospital of Jableh (Jableh-Syria) were selected from December 2015 until December 2016. Blood samples were collected for CRP levels on admission and measured by immunoturbidimetric determination, levels >5mg/l were considered positive. ER-receptor, PR-receptor and Her-2 expression were assessed.

Results

Triple positive receptors TP was the major subgroup of patients (n=21, 35%, p. value= 0.049). Relation between ER-receptor and PR-receptor expression was strongly significant (n= 37, 90.24%, p. value < 0.0001), Patients positive for Her-2 receptor expression were ≥46 years (n=27, 84.38%, p, value=0.039). Patients positive for serum CRP levels were positive for ER-receptor expression (n=26, 63.41%, p. value=0.021). Mean of CRP levels were increased with stage and difference was not significant. Patients with positive lymph nodes count >4 had higher grade (n=28, 75.78%, p. value= 0.009) and stage (n=24, 64.86%, p. value= 0.002), and were positive for PR-receptor expression (n=31, 83.71%, p. value= 0.008).

Conclusion

90% of patients have same histological diagnosis (invasive ductal carcinoma IDC), but present high variety of ER-receptor, PR-receptor and Her-2 receptor expression as heterogenic subtypes breast cancer, which propose different strategies of prevention and protocols of therapy. CRP levels could be a biomarker for invasive and progression of cancer according to stage and pN staging. Serum CRP levels could predict patients positive for ER-receptor, those who will benefit of modulation of ER-receptor expression as a routine strategy of prevention.

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Keywords

Breast cancer, estrogen receptor, progesterone receptor, lymph node metastasis, serum CRP levels.

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