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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 9
First page : ( 2857) Last page : ( 2862)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00503.0

Synthesis and Antimicrobial Evaluation of Novel Hybrid Antibiotics

Kumar Rohit, Gupta Vivek*, Narang Rakesh

Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi G.T. Road, Phagwara (Punjab) 144411, India

*Corresponding Author E-mail: vivek.15835@lpu.co.in

Online published on 16 May, 2018.

Abstract

Hybrid antibiotics are not found in nature as such. It is synthesized by combining the two or more antibiotics. Hybrid antibiotics can act through different modes of action combined in a single molecule. Molecules linked to one another by ester, amide, covalently bonded or by carbon chain linker. The expected benefits include activity against drug-resistant bacteria, an increased spectrum of activity and reduced chances for generating bacterial resistance. The formation of hybrid antibiotics having a synergistic effect to reduce the problem of antibacterial resistance. The main aim is to develop the hybrid molecules to increases the potency or synergistic effect as compared to giving them alone.

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Keywords

Antibiotic Resistance, Hybrid Antibiotics, Antimicrobial Evaluation, Sulphanilic acid, 6-Aminopenicillanic Acid, and Fluoroquinolones.

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