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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 8
First page : ( 2607) Last page : ( 2610)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00462.0

Genotyping of Angiotensin Converting Enzyme (ACE 1) Gene in study subject with hypertension and Chronic Kidney Disease

Suganya V1, Firdous Jannathul2,*, Karpagam T3, Varalakshmi B3, Shanmugapriya A3, Gomathi S3, Sugunabai J4

1Department of Biochemistry, Mohamed Sathak College of Arts and Science, Chennai, India

2Pre-Clincal Department, Faculty of Medicine, University Kuala Lumpur Royal College of Medicine Perak, No.3, Jalan Greentown, 30450 Ipoh, Perak, Malaysia

3Department of Biochemistry, Shrimati Indira Gandhi College, Tiruchirappalli, India

4Department of Biochemistry, Seethalakshmi Ramaswamy College, Tiruchirappalli, India

*Corresponding Author E-mail: Jannathul.firdous@unikl.edu.my

Online published on 26 March, 2018.

Abstract

Hypertension and Chronic kidney disease are two most prominent public health problems and show similar clinical complications like high blood pressure and poor renal system. These diseases are due to over activation of sympathetic nervous system. Genetically, the angiotensin-converting enzyme (ACE) gene is involved in hypertension and chronic kidney diseases where the D polymorphism is related to chronic kidney disease and hypertension. The objective of study is to correlate the absolute relationship between hypertension and renal complications in the polymorphism of ACE 1 gene. Results of statistical analysis conclude that none of the genotype distributions followed the Hardy-Weinberg equilibrium and the differences in genotypes or alleles were not statistically significant. The overall frequency of II genotype was 0.226, DD was 0.499 and ID was 0.276 respectively. Similarly, the frequency of I allele in the study population was 0.475 and D allele was 0.525 respectively. Although the results showed that ID genotype for ACE1 gene are found in hypertension and chronic kidney disease, large studies should be performed to verify the analysis.

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Keywords

Angiotensin converting enzyme, hypertension, chronic kidney disease and nested PCR.

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