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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 8
First page : ( 2543) Last page : ( 2550)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00450.4

Formulation and Evaluation of Mouth Dissolving Tablets of Clozapine by Direct Compression Method

Sravanthi N.1,*,  Alekhya1, Reddy I. Vikram2

1Pulla Reddy Institute of Pharmacy, Gummadidala, Domadugu

2Dr. Reddy's Laboratories Ltd, Bachupally, Hyderabad

*Corresponding Author E-mail: nalla.sravanti@gmail.com

Online published on 26 March, 2018.

Abstract

Mouth dissolving tablets overcomes the problem of swallowing, have faster onset of action. The present work focuses on preparation of Clozapine mouth dissolving tablets by direct compression method using various superdisintegrants and subliming agents. Six formulations were prepared and evaluated for Pre compression and post compression parameters. Effect of super disintegrant Crosspovidone and Explotab on wetting time, disintegration time, and drug content and in vitro release have been studied. values were found to be as16.76, 23.09. Comparative evaluation showed direct compression method a better alternative to sublimation method and rapidly disintegrate in oral cavity. Prepared by direct compression with Explotab superdisintegrants shows 99.79 while sublimation method using camphor 93.58 release in 12 min. Kinetic studies indicated that all the formulations followed first order release with fickian diffusion mechanism.

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Keywords

Clozapine, sublimation, direct compression, mouth dissolving.

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