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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 8
First page : ( 2446) Last page : ( 2450)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00432.2

Molecular Docking and In-vitro anti-inflammatory evaluation of Novel Isochromen-1-one analogues from Etodolac

Napoleon Ayyakannu Arumugam*, Sharma Vijay

Pharmaceutical Chemistry Laboratory SAS, VIT University, Vellore-632014, Tamil Nadu, India

*Corresponding Author E-mail: aanapoleon@vit.ac.in, napoleonaa@gmail.com

Online published on 26 March, 2018.

Abstract

In the present work, the three synthesized isochromen-1-one, their thio and N-methylated analogues derived from the anti-inflammatory drug Etodolac are assessed for its in-vitro anti-inflammatory activity and carried out molecular docking studies. Docking study result shows that compound, 5 possess good binding affinity with the COX-1 receptor showing a docking score of-8.2 and lipophilic interaction of-2.5 which is greater when compared to standard drugs such as Etodolac, Aceclofenac and Diclofenac were used. The same compound 5 also shows comparable in-vitro anti-inflammatory activity with etodolac as standard in both the methods screened.

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Keywords

Molecular docking, Isochromen-1-one, Etodolac, Isochromen-1-one analogues, Anti-inflammatory activity.

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