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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 7
First page : ( 2433) Last page : ( 2436)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00430.9

Prevalence of Extended Spectrum β Lactamases (ESBL) in E. coli at Al-Assad Teaching Hospital

Baaity Zain1,*, Almahmoud Iyad2, Khamis Atiea1

1Department of Department of Biochemistry and Microbiology, Faculty of Pharmacy, Tishreen University, Latakia, Syria

2Department of Microbiology, Faculty of Medicine, Tishreen University, Latakia, Syria

*Corresponding author E-mail: zein_syria@hotmail.com

Online published on 17 October, 2017.

Abstract

Increasing resistance to third-generation cephalosporins amongst E. coli and Klebsiella spp. is predominantly due to the production of extended-spectrum b-lactamases (ESBLs) and when wars take place, the public health crumples and healthcare facilities can't function as it should. This study aimed to determine prevalence of ESBL production status of E coli in isolates from Patients in Al-Assad Teaching Hospital during the awful crisis in Syria. Two hundred and thirty-six E. coli isolates n=236 were collected. Antibiotic susceptibility and ESBL production were studied by disc diffusion and DDST (double disk synergy tests) according to Clinical Laboratory Standards Institute guidelines (CLSI) and EUCAST for ESBL. 75 (32%)of total isolates demonstrated MDR (multi drug resistance), 62 of resistant bacteria (26% of total) were determined as ESBL producers.

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Keywords

E. coli, ESBL, Beta-Lactamase, Phenotype, MDR, DDST, Syria.

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