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Research Journal of Pharmacy and Technology
Year : 2017, Volume : 10, Issue : 7
First page : ( 2236) Last page : ( 2242)
Print ISSN : 0974-3618. Online ISSN : 0974-360X.
Article DOI : 10.5958/0974-360X.2017.00396.1

Role of Mdm2 Cascade in Human Cancers

Nayak Surendra Kumar1,*, Khatik Gopal Lal1, Narang Rakesh1, Monga Vikramdeep2

1Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi, G.T. Road (NH-1), Phagwara, Punjab-144411

2Department of Pharmaceutical Chemistry, Rajendra Institute of Technology and Sciences, Sirsa, Haryana-125055

*Corresponding Author E-mail: surendra_niper@yahoo.com

Online published on 17 October, 2017.

Abstract

Mdm2 is a well known oncogene which affects expression of various genetic factors. It encoded oncoprotein Mdm2 of 491 amino acids divided into four major domains (p53-binding, acidic, Zn-finger and ring finger). Acting as an E3-ubiquitin ligase, Mdm2 induced degradation of various proteins which affect the cellular transformation such as p53, p73, JMY, FOXO3a, HPIP, HDAC, p21Waf1/CIP1 etc. Thus, Mdm2 found to be responsible for up and down regulation proteins in cellular system and plays crucial role in several human cancers through variety of biological pathways. Here, we described the major classes of human cancers in which Mdm2 involved directly or indirectly. Moreover, mechanistic role of Mdm2 summarised along with intermediates of cellular biochemical pathways regulated or expressed by it.

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Keywords

Mdm2, p53, apoptosis, cancer, ubiquitination.

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